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The eye q formulation has been used
in various studies by some leading scientists
around the world, and can be seen as
a research-supported supplement.
In all of these collaborations, the
core aim was to assess whether the
formulation of hi-EPA marine lipid and
virgin EPO as natural source oils can help
maintain eye and brain function.
So we present here a summary of the
various research projects that have used
eye q, and explain the extent of Equazen's
involvement. The papers published
so far support the validity and
efficacy of the Equazen range of formulations.
Equazen’s philosophy is to assist researchers
as much as possible in projects that
will drive forward understanding in this
field. Equazen view it as imperative
that researchers have complete independence
in running trials and reporting their
results.
The Oxford-Durham Schools Trial
Full details are explained on www.durhamtrial.org,
but in short this is the most comprehensive
and thorough trial yet of how fatty acids
may be applied in the classroom.
This trial was run by the Durham
Local Education Authority in the UK,
and Equazen contributed free active and
placebo capsules. The first results published
in the American journal Pediatrics indicate
significant benefits for attention and
behaviour.
The BNK Trial
Results of this trial using the eye
q formulation were published in The
Journal of Attention Disorders in April 2008.
A total of 75 Swedish participants took
part in this 6 month randomised, double
blind, and placebo-controlled trial
with one-way crossover.
The aim was to assess whether omega3/6
fatty acid supplementation was effective
in the treatment of ADHD and its co-morbid
conditions in children and adolescents.
35 participants aged 8-18 years had ADHD
combined subtype and 40 participants
had ADHD inattentive subtype.
For the first 3 months participants
took either an omega 3/6 supplement (6
x eye q™ capsules per day) or a placebo
(olive oil). From 3 months to the end
of the trial all participants received
omega3/6 supplementation.
Assessments of ADHD symptoms was made
at baseline, 3 months and 6 months.
After 3 months a subgroup of 26% of
the active group (vs. 7% on placebo)
responded with a clinically meaningful
improvement of more than 25% reduction
of ADHD symptoms and a drop of CGI scores
into the near normal range.
After 6 months 47% of all showed such
improvement. Responders tended to be
more frequent in those with ADHD inattentive
subtype and neurodevelopmental disorders
(reading/writing difficulties, learning
disorder, developmental coordination
disorder and autism spectrum conditions.
The Adelaide Trial
Results from this large, clinical-based
omega-3 and omega-6 trial were published
in The
Journal of Developmental and Behavioural
Pediatrics, bolstering a growing
body of evidence to show that eye q can
improve ADHD symptoms in children including
inattention, hyperactivity and impulsivity.
The double-blind, randomised, placebo-controlled
trial was undertaken by The University
of South Australia and CSIRO Human Nutrition
and involved 132 children aged 7-12 with
ADHD symptoms.
Trial participants were given eye q
for 15 or 30 weeks. For the first 15
weeks, the children were divided into
three groups. One group took eye q, the
second group took eye q and a multi-vitamin/mineral
supplement, while the third group took
placebo palm oil capsules.
After 15 weeks all participating children
were given eye q and the multivitamins/minerals.
- Almost half (40-50%) of the children
taking eye q for the entire study saw
significant reductions in the core
symptoms of ADHD: inattention, hyperactivity
and impulsivity.
- According to the data, the multivitamin/mineral
supplement had no additional effects.
- The findings indicate that treatment
effects of omega-3 and omega-6 are
comparable with average treatment effects
of stimulant medication trials, based
on parent ratings of behaviour.
The Peterlee Sure Start Study
- Parents of children in the Sure Start
scheme in Peterlee County Durham were
invited to take part in a study to
investigate the effects of supplementation
on attention and behaviour in preschool
children.
- The children all took sachets of
eye q smooth during the study; our
naturally fruit flavoured (banana,
apricot, pineapple, lemon) liquid that
has the texture of yogurt. Its
easy 'tear off' top makes it ideal
for children as young as 2 years.
- 47 children between 20 and 36 months
completed this 5 month study. They
were observed by their parents who
rated their behaviour and concentration
using a 5 point scale from 'very good'
to 'very poor'.
- Whilst observational studies of this
type cannot show conclusive cause and
effect, they can give an indication
of benefit.
Some observations made at the end of
the study:
"The performance of the majority
of the children has improved dramatically. We
saw children whose learning skills went
from being six months below their chronological
age to age-equivalent in just three months."
"Some two-year-olds went from having
a vocabulary of up to 25 single words
to being able to use who sentences, while
others were able to sit down and concentrate
for the first time in their lives."
"Perhaps the most significant advantage
of this project is that the improvements
in behaviour of the children have facilitated
a much stronger bond between the parent
and child, and we think this has been
largely responsible for the development
of language and communication skills
in these children."
The Greenfield Study
Greenfield Arts & Community College,
a secondary school in County Durham identified
20 pupils aged between 12 and 15 years
who exhibited concentration and behaviour
problems.
Teachers completed a Connor's' Teacher
Rating Scale (CTRS) at baseline and 3
months after supplementation with eye
q to provide an indication of behavioural
problems according to ADHD criteria.
The reductions in attention and hyperactive-impulsive
behaviour were very promising.
The Eaton Hall Special School Study
Eaton Hall is Norwich County Council's
specialist school for boys with behavioural,
social and emotional difficulties. 28
pupils aged 10-16 years were given eye
q together with eating a healthy balanced
diet, for 6 months.
Staff reported that there was a 49%
reduction in total incidents (managed
and non-physical) compared with the previous
period, and 68% reduction in physically
managed incidents.
The Sunderland Autism Study
This major project is being run by Sunderland
University's Autism Research Unit, in
conjunction with the Durham LEA, and
is aimed at assessing the effects of
omega-3 and -6 fatty acids in features
of autistic spectrum disorder.
Other research published in the leading
fatty acid journal, PLEFA, using eye
q, has shown that it does alter the blood
fatty acid profile of autistic spectrum
subjects.
Equazen has contributed free active
and placebo capsules for the Sunderland
trial.
MRI Work on Chronic Fatigue Syndrome
eye q has been used to see if it can
help with Chronic Fatigue Syndrome, in
before-and-after assessments based on
MRI scans.
The encouraging results were published
in three peer-reviewed journals; The
International Journal of Clinical Practice,
PLEFA and Acta Psychiatry Scandinavia.
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